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Abstract
A B S T R A C T
Trials in pre-clinical trials are very complex multidisciplinary studies. Extrapolating
data from animals to humans requires information from many fields of science. From
pre-clinical trials, more detailed information and data on efficacy and safety were
obtained, especially at doses equivalent to doses in humans, and the presence or
absence of cumulative effects and whether these effects could return to normal
(reversible) after the administration of the test material was stopped. This test can
be used to predict the negative impact on humans if he is exposed to the material
for a long time.
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