Management of Rare Secondary Full-Thickness Macular Hole in Proliferative Diabetic Retinopathy: Inverted ILM Flap Technique with Extended Surgical Follow-up

Authors

  • I Gusti Ngurah Dhyana Yoga Department of Ophthalmology, Faculty of Medicine, Universitas Udayana/Prof. Dr. I.G.N.G. Ngoerah General Hospital, Denpasar, Indonesia
  • Ari Andayani Department of Ophthalmology, Faculty of Medicine, Universitas Udayana/Prof. Dr. I.G.N.G. Ngoerah General Hospital, Denpasar, Indonesia
  • Ni Made Ari Suryathi Department of Ophthalmology, Faculty of Medicine, Universitas Udayana/Prof. Dr. I.G.N.G. Ngoerah General Hospital, Denpasar, Indonesia

DOI:

https://doi.org/10.37275/bsm.v10i6.1616

Keywords:

Full-thickness macular hole, Internal limiting membrane flap, Proliferative diabetic retinopathy, Tractional retinal detachment, Vitreoretinal surgery

Abstract

Background: Secondary full-thickness macular hole (FTMH) in proliferative diabetic retinopathy (PDR) is rare, occurring in only 1-4% of PDR cases. Combined with tractional retinal detachment (TRD), this complication presents significant surgical challenges. The inverted internal limiting membrane (ILM) flap technique remains under-utilized in this specific setting.

Case presentation: A 61-year-old Indonesian male with type 2 diabetes (>15 years), chronic kidney disease, and cardiovascular disease presented with sudden vision loss (best-corrected visual acuity 1/300). Examination revealed superior TRD (2-11 o'clock) and large FTMH (CMT 249 micrometers). After intravitreal bevacizumab (August 9th, 2024), he underwent 360-degree pars plana vitrectomy with inverted ILM flap and silicone oil tamponade (August 14th, 2024). Inferior redetachment at 2 months necessitated re-vitrectomy with endolaser and silicone oil evacuation (October 23rd, 2024). At final follow-up (12 weeks post-second surgery), the patient achieved complete retinal reattachment with normalized macular anatomy, visual acuity 1/60, and intraocular pressure 10 mmHg.  

Conclusion: Despite severe baseline disease and comorbidities, stepwise surgical strategy incorporating preoperative anti-VEGF therapy, comprehensive traction release, inverted ILM flap reconstruction, and staged procedures yielded meaningful anatomical recovery. This case supports inverted ILM flap utility in PDR-related secondary FTMH.

Authors

  • I Gusti Ngurah Dhyana Yoga1*
  • Ari Andayani1
  • Ni Made Ari Suryathi1
  1. 1Department of Ophthalmology, Faculty of Medicine, Universitas Udayana/Prof. Dr. I.G.N.G. Ngoerah General Hospital, Denpasar, Indonesia

Corresponding author I Gusti Ngurah Dhyana Yoga — yogajangkungs@gmail.com

Article history

  1. Submitted
  2. Accepted
  3. Published

Downloads

Published

2026-04-24

Article metrics

140Abstract views
136PDF downloads

How to Cite

1.
I Gusti Ngurah Dhyana Yoga, Ari Andayani, Ni Made Ari Suryathi. Management of Rare Secondary Full-Thickness Macular Hole in Proliferative Diabetic Retinopathy: Inverted ILM Flap Technique with Extended Surgical Follow-up. Bioscmed [Internet]. 2026 Apr. 24 [cited 2026 Aug. 15];10(6):2300-16. Available from: https://bioscmed.com/index.php/bsm/article/view/1616